Palladium-Catalyzed C-7 Selective CH Carbonylation of Indolines for Expedient Synthesis of Pyrroloquinazolinediones

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• 作者：Pei-Long Wang ; Yan Li ; Lan Ma ; Chen-Guang Luo ; Zhen-Yu Wang ; Quan Lan and Xi-Sheng Wang
• 关键词：carbon monoxide ; CH carbonylation ; indolines ; palladium catalysis ; pyrroloquinazolinediones
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2016
• 出版时间：March 31, 2016
• 年：2016
• 卷：358
• 期：7
• 页码：1048-1053
• 全文大小：820K
• ISSN：1615-4169

文摘

A novel palladium-catalyzed C-7 selective CH carbonylation of indolines with carbon monoxide for an expedient synthesis of pyrroloquinazolinediones, a structural motif with great potential in biologically active compounds, has been developed. Oxidation of the pyrroloquinazolinedione with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) could easily afford the corresponding indole-based derivative in excellent yield.