Synthesis of Tricyclic Isoquinoline Derivatives via Palladium- Catalyzed Tandem Reactions of 2,7-Alkadiynylic Carbonates with 2,3-Allenyl Sulfamides

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• 作者：Xin Huang ; Wangteng Wu ; Shihua Song ; Chunling Fu and Shengming Ma
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2016
• 出版时间：September 1, 2016
• 年：2016
• 卷：358
• 期：17
• 页码：2791-2805
• 全文大小：819K
• ISSN：1615-4169

文摘

The palladium-catalyzed tandem reactions of 2,7-alkadiynylic carbonates with 2,3-allenyl sulfamides for the syntheses of fused tricycles such as 1,3,6,7,8,9-hexahydrofuro[3,4-h]isoquinoline, 2,3,6,7,8,9-hexahydro-1H-pyrrolo[3,4-h]isoquinoline, and 2,3,4,7,8,9-hexahydro-1H-cyclopenta[h]isoquinoline derivatives have been developed. A mechanism has been proposed based on the isolation of a by-product.