Carbazoles from the [4C+2C] Reaction of 2,3-Allenols with Indoles

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• 作者：Dr. Binjie Guo ; Dr. Xin Huang ; Prof. Dr. Chunling Fu and Prof. Dr. Shengming Ma
• 刊名：Chemistry - A European Journal
• 出版年：2016
• 出版时间：December 19, 2016
• 年：2016
• 卷：22
• 期：51
• 页码：18343-18348
• 全文大小：759K
• ISSN：1521-3765

文摘

A mild and efficient method using readily available 1-aryl-2,3-allenols and unprotected-N indoles, Au⁺-catalyzed cyclization, and aromatization to afford the final [4C+2C] products, carbazoles 4, with an excellent selectivity, is reported. The reaction demonstrates excellent regioselectivity and allows the N−H unit to undergo reactivity unprotected. A mechanism involving a spiropolycyclic intermediate has been proposed and synthetic application is also demonstrated.