American Journal of Transplantation: Volume 17, Number 2, February 2017

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• 刊名：American Journal of Transplantation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：17
• 期：2
• 全文大小：1094K
• ISSN：1600-6143

文摘

On the cover this month: Acquired immune responses are thought to be focused by specificity (e.g. foreign alloantigen), but are increasingly believed to be driven by broader signals indicating that a cell is in distress. This month, Matta et al (com/doi/10.1111/ajt.13887/abstract" rel="references:http://onlinelibrary.wiley.com/doi/10.1111/ajt.13887/abstract">page 320) provide a concise update on alarmins—small molecules released from distressed cells that provoke immune activation and amplification. We also provide a minireview by Scozzi et al (com/doi/10.1111/ajt.13940/abstract" rel="references:http://onlinelibrary.wiley.com/doi/10.1111/ajt.13940/abstract">page 328) that addresses neutrophils and their role in alloimmune response initiation, and an insightful paper by Lobb et al (com/doi/10.1111/ajt.14080/abstract" rel="references:http://onlinelibrary.wiley.com/doi/10.1111/ajt.14080/abstract">page 341); also see the related editorial from Hauet and Thuillier on com/doi/10.1111/ajt.14150/abstract" rel="references:http://onlinelibrary.wiley.com/doi/10.1111/ajt.14150/abstract">page 313 focusing on mitochondrial damage as a central source of innate signals of cellular injury. Together, these articles help shine light on the antigen-independent mechanisms of alloimmunity. Cover design by Scott Behm, Duke University Department of Surgery.