Gold-Catalyzed Oxidation/C−H Functionalization of Ynones: Efficient and Rapid Access to Functionalized Polycyclic Salicyl Ketones

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• 作者：Prof. Dr. Kegong Ji ; Dr. Fang Yang ; Shiyue Gao ; Dr. Jiangjiang Tang and Prof. Dr. Jinming Gao
• 刊名：Chemistry - A European Journal
• 出版年：2016
• 出版时间：July 11, 2016
• 年：2016
• 卷：22
• 期：29
• 页码：10225-10229
• 全文大小：826K
• ISSN：1521-3765

文摘

An efficient strategy to construct salicyl ketones through gold-catalyzed oxidation/C−H functionalization of ynones is reported. A variety of functionalized salicyl ketones are readily accessed by utilizing this non-diazo approach, thus providing a viable alternative to synthetically useful salicyl ketones with a yield up to 98 %. The α-oxo gold carbenes generated in situ through gold-catalyzed oxidation of ynones can be trapped effectively by internal aryl and heteroaromatic groups. Electronic and steric effects were also investigated in this reaction. The anticancer activity of one salicyl ketone analogue was investigated and its cytotoxicity assays against the PC-3 prostate cancer cell line and SKOV-3 human ovarian carcinoma cell line yield IC₅₀ were 0.81±0.05 and 0.87±0.15 μm, respectively, demonstrating that salicyl ketone analogues showed good anticancer activity.