PCL-PEG-PCL film promotes cartilage regeneration in vivo

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• 作者：Na Fu ; Jinfeng Liao ; Shiyu Lin ; Ke Sun ; Taoran Tian ; Bofeng Zhu and Yunfeng Lin
• 刊名：Cell Proliferation
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：49
• 期：6
• 页码：729-739
• 全文大小：1942K
• ISSN：1365-2184

文摘

Management of chondral defects has long been a challenge due to poor self-healing capacity of articular cartilage. Many approaches, ranging from symptomatic treatment to structural cartilage regeneration, have obtained very limited satisfactory results. Cartilage tissue engineering, which involves optimized combination of novel scaffolds, cell sources and growth factors, has emerged as a promising strategy for cartilage regeneration and repair. In this study, the aim was to investigate the role of poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) PCEC scaffold in cartilage repair.