Back Cover: Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity (ChemMedChem 14/2016)

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• 作者：Huy X. Ngo ; Dr. Sanjib K. Shrestha and Prof. Sylvie Garneau-Tsodikova
• 刊名：ChemMedChem
• 出版年：2016
• 出版时间：July 19, 2016
• 年：2016
• 卷：11
• 期：14
• 页码：1577
• 全文大小：3181K
• ISSN：1860-7187

文摘

<b>The back cover picture showsb> an ebsulfur analogue that displays antifungal activity against various clinically relevant fungal m>Candidam> and m>Aspergillusm> strains, which are either equivalent or superior to the currently used antifungal drugs. The preliminary antifungal mechanism of action was determined to be correlated with an increase in reactive oxygen species. The safety of this ebsulfur analogue compound was evaluated and found to be comparable with ebselen, an analogous molecule now in clinical trials, in terms of mammalian toxicity. Overall, this work could potentially lead to development of new potent orally active antifungal agents to assist the current antifungal repertoire. More information can be found in the Full Paper by Sylvie Garneau-Tsodikova et al. on <b>page 1507 in Issue 14, 2016b> (DOI:mdc.201600236" rel="references:http://dx.doi.org/10.1002/cmdc.201600236">10.1002/cmdc.201600236).