Seven New Acyl Glycosides from Erycibe obtusifolia
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- 作者：Zi-Ming Feng ; Zhao-Zhen Liu ; Kuo Xu ; Ya-Nan Yang ; Jian-Shuang Jiang and Pei-Cheng Zhang
- 关键词：Erycibe obtusifolia ; Acyl glycosides ; Cytotoxic activity
- 刊名：Helvetica Chimica Acta
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：99
- 期：3
- 页码：197-203
- 全文大小：187K
- ISSN：1522-2675
文摘
Seven new acyl glycosides, benzyl 5-O-vanilloyl-β-d-apiofuranosyl-(16)-β-d-glucopyranoside (1), 4-hydroxy-3-methoxyphenyl 5-O-syringoyl-β-d-apiofuranosyl-(16)-β-d-glucopyranoside (2), isopentyl 5-O-syringoyl-β-d-apiofuranosyl-(16)-β-d-glucopyranoside (3), 3,4,5-trimethoxyphenyl 5-O-sinapoyl-β-d-apiofuranosyl-(16)-β-d-glucopyranoside (4), 6-methoxy-7-[(6-O-sinapoyl-β-d-glucopyranosyl)oxy]coumarin (5), 6-methoxy-7-[(2-O-sinapoyl-β-d-glucopyranosyl)oxy]coumarin (6), and isopentyl β-d-apiofuranosyl-(16)-[5-O-syringoyl-β-d-apiofuranosyl-(12)]-β-d-glucopyranoside (7), were isolated from Chinese folk herb Erycibe obtusifolia. Their structures were elucidated on the basis of extensive spectroscopic analysis, including UV, IR, MS, and 1D- and 2D-NMR techniques. Further, these compounds were evaluated against HCT-8 (human colon carcinoma), Bel-7402 (human liver carcinoma), BGC-823 (human stomach carcinoma), A549 (human lung carcinoma), and A2780 (human ovarian carcinoma) cell lines, however, none of them exhibited a significant bioactivity (IC50 > 10 μm).