Synthesis and characterization of novel biocompatible palm oil-based alkyds
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- 作者：Siew Yong Teo ; Siang Yin Lee ; Allan Coombes ; Michael John Rathbone and Seng Neon Gan
- 刊名：European Journal of Lipid Science and Technology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：118
- 期：8
- 页码：1193-1201
- 全文大小：403K
- ISSN：1438-9312
文摘
Novel alkyds of short, medium, and long oil length were synthesized using a two-stage alcoholysis-polyesterification method from bio-sourced starting materials. Alcoholysis reaction mixtures of palm kernel oil and glycerol underwent transesterification to convert triglycerides to monoglycerides within 3 h. Kinetic studies showed that the polyesterification reaction rates obeyed second order kinetics up to 15 min, followed by chain branching and crosslinking. The alkyd chemical structure was confirmed by nuclear magnetic resonance and Fourier Transform infrared spectroscopy. Gel permeation chromatography revealed that the average molecular weight of the alkyds was confined to <2,000 Da which is advantageous for the production of nanoscale drug carriers. Differential scanning calorimetry showed that the alkyds possess low glass transition temperatures within a very narrow range of −49.3°C–−52.7°C. Thermogravimetric analysis revealed good thermal stability with alkyd degradation occurring above 200°C. Cell viability assay confirmed that the alkyds were non-toxic to 3T3 mouse fibroblasts following exposure of cell cultures for 24 h to solutions of concentration ranging from 3 to 100 μg/mL. These findings highly recommend consideration of the novel, bio-sourced alkyds for pharmaceuticals manufacture and controlling drug delivery.