Neuroendocrine neoplasms of the sinonasal region
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- 作者：Diana Bell ; Ehab Y. Hanna ; Randal S. Weber ; Franco DeMonte ; Asterios Triantafyllou ; James S. Lewis Jr ; Antonio Cardesa ; Pieter J. Slootweg ; Gö ; ran Stenman ; Douglas R. Gnepp ; Kenneth O. Devaney ; Juan P. Rodrigo ; Alessandra Rinaldo ; Bruce M. Wenig ; William H. Westra ; Justin A. Bishop ; Henrik Hellquist ; Jennifer L. Hunt ; Kimihide Kusafuka ; Bayardo Perez-Ordoñ ; ez ; Michelle D. Williams ; Robert P. Takes and Alfio Ferlito
- 关键词：neuroendocrine neoplasms ; olfactory neuroblastoma ; sinonasal carcinoma ; immunohistochemistry ; sinonasal undifferentiated carcinoma
- 刊名：Head & Neck
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：38
- 期：S1
- 页码：E2259-E2266
- 全文大小：5934K
- ISSN：1097-0347
文摘
Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small-cell and large-cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high-grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined.