Vascular hepoxilin and trioxilins mediate vasorelaxation through TP receptor inhibition in mouse arteries
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- 作者：L. Siangjong ; D. H. Goldman ; T. Kriska ; K. M. Gauthier ; E. M. Smyth ; N. Puli ; G. Kumar ; J. R. Falck and W. B. Campbell
- 刊名：Acta Physiologica
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：219
- 期：1
- 页码：188-201
- 全文大小：1016K
- ISSN：1748-1716
文摘
12/15-lipoxygenase (12/15-LO) metabolizes arachidonic acid (AA) into several vasoactive eicosanoids. In mouse arteries, we previously characterized the enzyme's 15-LO metabolites 12(S)-hydroxyeicosatetraenoic acid (HETE), 15-HETE, hydroxyepoxyeicosatrienoic acids (HEETAs) and 11,12,15-trihydroxyeicosatrienoic acids (11,12,15-THETAs) as endothelium-derived relaxing factors. However, the observed 12-LO metabolites remained uncharacterized. The purpose of this study was to determine the structure and biological functions of eicosanoids generated by the enzyme's 12-LO activity.