Effects of Interaction Between Ventricular Assist Device Assistance and Autoregulated Mock Circulation Including Frank-Starling Mechanism and Baroreflex

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• 作者：So-Hyun Jansen-Park ; Mohammad Nauzef Mahmood ; Indra Mü ; ller ; Lisa Kathrin Turnhoff ; Thomas Schmitz-Rode ; Ulrich Steinseifer and Simon Johannes Sonntag
• 刊名：Artificial Organs
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：40
• 期：10
• 页码：981-991
• 全文大小：651K
• ISSN：1525-1594

文摘

A mock heart circulation loop (MHCL) is a hydraulic model simulating the human circulatory system. It allows in vitro investigations of the interaction between cardiac assist devices and the human circulatory system. In this study, a preload sensitive MHCL, the MHCL_AUTO, was developed to investigate the interaction between the left ventricle and left ventricular assist devices (LVADs). The Frank–Starling mechanism was modeled by regulating the stroke volume (SV) based on the measured mean diastolic left atrial pressure (MLAP_diast). The baroreflex autoregulation mechanism was implemented to maintain a constant mean aortic pressure (MAP) by varying ventricular contractility (E_max), heart rate (HR), afterload/systemic vascular resistance (SVR) and unstressed venous volume (UVV). The DP3 blood pump (Medos Medizintechnik GmbH) was used to simulate the LVAD. Characteristic parameters were measured in pathological conditions both with and without LVAD to assess the hemodynamic effect of LVAD on the MHCL_AUTO. The results obtained from the MHCL_AUTO show a high correlation to literature data. The study demonstrates the possibility of using the MHCL_AUTO as a research tool to better understand the physiological interactions between cardiac implants and human circulation.