Crystal engineering: co-crystals of cinnamic acid derivatives with a pyridyl derivative co-crystallizer
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- 作者：Daniel A. Lorenzo ; Sebastian J. K. Forrest and Hazel A. Sparkes
- 关键词：co-crystal ; cinnamic acid ; solvent drop grinding
- 刊名：Acta Crystallographica Section B
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：72
- 期：1
- 页码：87-95
- 全文大小：1300K
- ISSN：2052-5206
文摘
A number of hydrogen-bonded co-crystals, consisting of a cinnamic acid derivative and a pyridyl co-crystallizer, have been synthesized and their properties investigated by X-ray diffraction. Samples were prepared by recrystallization or solvent drop grinding of trans-cinnamic acid (1), 4-methylcinnamic acid (2), 4-methoxy cinnamic acid (3) or 3,4-methoxy cinnamic acid (4), with 4,4-dipyridyl (A), iso-nicotinamide (B) or nicotinamide (C). The X-ray single-crystal structures of seven novel co-crystals, obtained through recrystallization, are examined and the hydrogen-bonding interactions discussed. Consistent hydrogen-bonding motifs were observed for samples prepared when using 4,4-dipyridyl (A) or iso-nicotinamide (B) as the co-crystallizing agent. Powder X-ray diffraction analysis of the samples prepared by solvent drop grinding suggests the formation of ten co-crystals.