Triphenylphosphine (PPh₃) Catalyzed Erlenmeyer Reaction for Azlactones under Solvent-free Conditions

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• 作者：Alapati Mohan Lakshmi Punna Rao ; Abburi Sridhar Rao ; Mukkamala Saratchandra Babu and M. Krishnaji Rao
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：429-435
• 全文大小：1969K
• ISSN：1943-5193

文摘

This study presents triphenylphosphine catalyzed process for the synthesis of azlactones and their derivatives using hippuric and substituted aromatic aldehydes. The methodology also found to be effective for the synthesis of azlactones from 5-(2,6-dichlorophenyl)-3-methyl-1,2-oxazol-4-yl carbonyl amino acetic acid and offers several advantages such as solvent-free conditions, excellent yields, simple procedure, mild conditions, and reduced environmental consequences.