Escherichia coli-derived and Staphylococcus aureus-derived extracellular vesicles induce MUC5AC expression via extracellular signal related kinase 1/2 and p38 mitogen-activated protein kinase in human airway epithelial cells

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• 作者：Chang Hoon Bae ; Yoon Seok Choi ; Si-Youn Song ; Yoon-Keun Kim and Yong-Dae Kim
• 刊名：International Forum of Allergy & Rhinology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：7
• 期：1
• 页码：91-98
• 全文大小：943K
• ISSN：2042-6984

文摘

Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) release extracellular vesicles (EVs). E. coli–derived and S. aureus–derived EVs are associated with neutrophilic respiratory inflammation. In neutrophilic respiratory inflammation of human, expression of mucin is increased in airway epithelial cells and is associated with increased morbidity and mortality of the affected patients. However, no study on the effects of EVs on expression of mucin genes has been reported in airway epithelial cells. Therefore, this study was conducted in order to examine the effects and the brief signaling pathways of E. coli–derived and S. aureus–derived EVs on MUC5AC expression in human airway epithelial cells.