Development and Validation of Voriconazole Concentration by LC-MS-MS: Applied in Clinical Implementation
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- 作者：Santirat Prommas ; Apichaya Puangpetch ; Nuttawut Jenjirattithigarn ; Sumonrat Chuwongwattana ; Thawinee Jantararoungtong ; Napatrupron Koomdee ; Siwalee Santon ; Montri Chamnanphon and Chonlaphat Sukasem
- 刊名：Journal of Clinical Laboratory Analysis
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：31
- 期：1
- 全文大小：209K
- ISSN：1098-2825
文摘
Voriconazole (VRZ) is a triazole antifungal used for treatment of invasive fungal infection, which is a life-threatening condition. Therapeutic drug monitoring is recommended for identifying the optimal dose in patients who have hepatic/renal impairment or reduced function of the CYP2C19 metabolizing enzyme.