Pulsed and oscillating gradient MRI for assessment of cell size and extracellular space (POMACE) in mouse gliomas
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- 作者：Olivier Reynaud ; Kerryanne Veronica Winters ; Dung Minh Hoang ; Youssef Zaim Wadghiri ; Dmitry S. Novikov and Sungheon Gene Kim
- 刊名：NMR in Biomedicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：29
- 期：10
- 页码：1350-1363
- 全文大小：673K
- ISSN：1099-1492
文摘
Solid tumor microstructure is related to the aggressiveness of the tumor, interstitial pressure and drug delivery pathways, which are closely associated with treatment response, metastatic spread and prognosis. In this study, we introduce a novel diffusion MRI data analysis framework, pulsed and oscillating gradient MRI for assessment of cell size and extracellular space (POMACE), and demonstrate its feasibility in a mouse tumor model.