A new route for the synthesis of su
bstituted 8-methyl-6-phenyl-5,6-dihydro-4
H-1,3,2-
benzodioxaphosphocine-2-oxide derivatives has
been developed
by using
brary/content/render" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2638-eo-0002">cinnamic acid and
brary/content/render" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2638-eo-0001">p-cresol via condensation, reduction, and followed
by
phosphorylation steps. The title compounds were characterized
by IR,
1H,
13C,
31P, and mass spectral studies and elemental analysis. The title compounds have
been investigated for their antioxidant activity with respect to their IC
b>50b> values using 2,2-diphenyl-1-picrylhydrazyl, NO radical scavenging activities, and reducing power assay. The results o
btained from the aforementioned methods revealed that 2-phenylamino derivatives have shown greater free radical scavenging activity when compared with those of the phenoxy derivatives and is attri
buted to the presence of secondary amino group, which is a
ble to produce free radicals easily.