Interaction Between Orexin-A and Sleep Quality in Females in Extreme Weight Conditions

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• 作者：Sarah Sauchelli ; Susana Jim&eacute ; nez-Murcia ; Jose C. Ferná ; ndez-Garcí ; a ; Lourdes Garrido-Sá ; nchez ; Francisco J. Tinahones ; Felipe F. Casanueva ; Rosa M. Bañ ; os ; Cristina Botella ; Ana B. Crujeiras ; Rafael de la Torre ; Jose M. Ferná ; ndez-Real ; Gema Frü ; hbeck ; Roser Granero ; Francisco J. Ortega ; Amaia Rodrí ; guez ; Stephan Zipfel ; Katrin E. Giel ; Jose M. Menchó ; n and Fernando Ferná ; ndez-Aranda
• 刊名：European Eating Disorders Review
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：24
• 期：6
• 页码：510-517
• 全文大小：162K
• ISSN：1099-0968

文摘

The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orexin-A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy-weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist-90-Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin-A levels (p = .050), greater depression, anxiety and somatization symptoms (all: p < .001), and impoverished self-reported sleep quality (p < .001). A quadratic trend was found in objective sleep time, being longest in the obese group (p = .031). Structural equation modelling showed plasma orexin-A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexin-A concentrations and poor sleep that contributes to fluctuations in body mass index. Copyright