Enhanced uptake of blood coagulation factor VIII containing immune complexes by antigen presenting cells
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- 作者：R. B. Hartholt ; A. Wroblewska ; E. Herczenik ; I. Peyron ; A. ten Brinke ; T. Rispens ; M. A. Nolte ; E. Slot ; J. W. Claassens ; F. Nimmerjahn ; J. S. Verbeek and J. Voorberg
- 刊名：Journal of Thrombosis and Haemostasis
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：15
- 期：2
- 页码：329-340
- 全文大小：530K
- ISSN：1538-7836
文摘
A major complication in the treatment of hemophilia A is the development of inhibitory antibodies targeting coagulation factor VIII (FVIII). Eradication of these inhibitors can be established by immune tolerance induction (ITI), which consists of daily administration of high dosages of FVIII. FVIII immune complexes (FVIII-IC) could be formed following FVIII infusion in patients with pre-existing anti-FVIII antibodies.