Influence of Chemical Composition on the Bioactivity of Spray Pyrolyzed Mesoporous Bioactive Glass

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• 作者：Shao-Ju Shih ; Dyka Rahayu Meyla Sari and Yu-Chien Lin
• 刊名：International Journal of Applied Ceramic Technology
• 出版年：2016
• 出版时间：July/August 2016
• 年：2016
• 卷：13
• 期：4
• 页码：787-794
• 全文大小：608K
• ISSN：1744-7402

文摘

SiO₂-CaO-P₂O₅-based mesoporous bioactive glass (MBG) is a potential material for bone implants due to its superior bioactivity. Sol-gel is a common technique for preparing MBG. Early studies showed that for MBG, the composition and surface area have critical influences on the bioactivity of MBG. However, there is a counteractive effect if both factors are used to enhance the bioactivity of MBG: a higher Ca content (lower Si content) provides more nonbridging oxygen groups, which enhance the bioactivity, but a higher Ca content also allows a lower viscosity at high temperature. Low viscosity is not able to prevent the MBG liquid flowing into the mesopores and results in the reduction of the surface area, which deteriorates the bioactivity. Unlike sol-gel, spray pyrolysis (SP) offers a rapid cooling rate, which can avoid the lower viscosity and resultant damage to the mesoporous structure, and the rapid cooling rate also preserves more metastable siloxane groups, which enhance the bioactivity. In this study, MBG particles with various Si:Ca ratios were synthesized using SP, and the morphology and bioactivity were investigated. Two typical morphologies, spherical mesoporous and wrinkled mesoporous, were observed. Also, a faster hydroxyl apatite formation time was observed in MBG with lower silica concentration (70 mol% SiO₂).