Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism
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- 作者：Naoyuki Makita ; Jun Ishiguro ; Keisuke Suzuki and Futoshi Nara
- 刊名：Journal of Pharmacy and Pharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：69
- 期：1
- 页码：43-51
- 全文大小：565K
- ISSN：2042-7158
文摘
Recently, there has been a growing interest in the mechanism of action of dichloroacetate (DCA) for T-cell differentiation; however, this mechanism has not been elucidated in detail. Therefore, this study aimed to investigate the mechanism of action of DCA for Treg and Th17 differentiation with pyruvate dehydrogenase kinase (PDHK) inhibitor (AZD7545) and PDHK knockdown.