Synthesis of Imidazole and Theophylline Derivatives Incorporating Pyrimidine-Fused Heterocycles Using Magnetic Nanoparticles-Supported Tungstic Acid (MNP-TA) Catalyst

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• 作者：Masoumeh Divar ; Farhad Panahi ; Sayedeh Rojin Shariatipour and Ali Khalafi-Nezhad
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：660-669
• 全文大小：1164K
• ISSN：1943-5193

文摘

In the current study, divers pyrimidine-fused heterocycles containing an imidazole, benzimidazole, or theophylline moieties were synthesized. For the synthesis of this category of compounds, first, some new bromo-substituted aldehydes (BSAs) were synthesized using reaction of der" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2639-eo-0001">der" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2639-eo-0002">4-hydroxybenzaldehyde and dibromides. Then, BSAs were reacted with imidazole, benzimidazole, and theophylline in order to synthesize corresponding heterocyclic-substituted aldehydes (HSAs). Finally, the synthesized HSAs underwent in a multi-components reaction with barbituric acids, amines, and der" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2639-eo-0006">dimedone in the presence of magnetic nanoparticles-supported tungstic acid (MNP-TA) catalyst in order to synthesis target products in good to excellent yields. The MNP-TA was reusable using an external magnetic field and providing a clean and efficient reaction conditions for efficient synthesis of this class of compounds.