Partial Protection by Dietary Antioxidants Against Ethanol-Induced Osteopenia and Changes in Bone Morphology in Female Mice:
详细信息 查看全文
- 作者：Alexander W. Alund ; Kelly E. Mercer ; Casey F. Pulliam ; Larry J. Suva ; Jin-Ran Chen ; Thomas M. Badger and Martin J. J. Ronis
- 刊名：Alcoholism: Clinical and Experimental Research
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：41
- 期：1
- 页码：46-56
- 全文大小：639K
- ISSN：1530-0277
文摘
Chronic alcohol consumption leads to increased fracture risk and an elevated risk of osteoporosis by decreasing bone accrual through increasing osteoclast activity and decreasing osteoblast activity. We have shown that this mechanism involves the generation of reactive oxygen species (ROS) produced by NADPH oxidases. It was hypothesized that different dietary antioxidants, N-acetyl cysteine (NAC; 1.2 mg/kg/d), and α-tocopherol (Vit.E; 60 mg/kg/d) would be able to attenuate the NADPH oxidase-mediated ROS effects on bone due to chronic alcohol intake.