文摘
A recently characterized group of undifferentiated small round cell sarcomas harbours fusions of the genes <em>CICem> and <em>DUX4em>. Studies report a distinctive gene expression profile for these sarcomas, including expression of E26 transformation-specific (ETS) family proto-oncogenic transcription factors <em>ETV1, ETV4em> and <em>ETV5em>. To test the utility of an ancillary diagnostic technique for these tumours, we evaluated chromogenic RNA <em>in-situem> hybridization assays for <em>ETV1em>,<em> ETV4em> and <em>ETV5em> as diagnostic adjuncts for this emerging group of highly malignant sarcomas.