Human papillomavirus-related oropharyngeal cancer: HPV and p16 status in the recurrent versus parent tumor

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• 作者：Jeffrey Vainshtein ; Jonathan B. McHugh ; Matthew E. Spector ; Heather M. Walline ; Christine M. Komarck ; Matthew H. Stenmark ; Mark E. Prince ; Francis P. Worden ; Gregory T. Wolf ; Carol R. Bradford ; Douglas B. Chepeha ; Thomas Carey and Avraham Eisbruch
• 关键词：human papillomavirus ; p16 ; oropharyngeal cancer ; expression profiling ; chemoradiation
• 刊名：Head & Neck
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：37
• 期：1
• 页码：8-11
• 全文大小：84K
• ISSN：1097-0347

文摘

Although typically associated with a favorable prognosis, a minority of human papillomavirus (HPV)-related (+) oropharyngeal cancers recur after chemoradiation. We postulated that a minor HPV-negative tumor subfraction may be responsible for recurrences of HPV+ oropharyngeal cancer.