Activation of nucleotide-binding domain-like receptor containing protein 3 inflammasome in dendritic cells and macrophages by Streptococcus sanguinis

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• 作者：Ayumi Saeki ; Toshihiko Suzuki ; Akira Hasebe ; Ryousuke Kamezaki ; Mari Fujita ; Futoshi Nakazawa and Ken-Ichiro Shibata
• 刊名：Cellular Microbiology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：19
• 期：3
• 全文大小：1249K
• ISSN：1462-5822

文摘

Streptococcus sanguinis is frequently isolated from the blood of patients with infective endocarditis and contributes to the pathology of this disease through induction of interleukin (IL)-1β responsible for the development of the disease. However, the mechanism of IL-1β induction remains unknown. In this study, S. sanguinis activated a murine dendritic cell (DC) to induce IL-1β and this activity was attenuated by silencing the mRNAs of nucleotide-binding domain-like receptor containing protein 3 (NLRP3) and caspase-1.