Solvent-Mediated Polymorphic Transformation of -Taltirelin by Seeded Crystallization

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• 作者：Dang Le Tri Nguyen and Kwang-Joo Kim
• 刊名：Chemical Engineering & Technology
• 出版年：2016
• 出版时间：July, 2016
• 年：2016
• 卷：39
• 期：7
• 页码：1281-1288
• 全文大小：654K
• ISSN：1521-4125

文摘

Solvent-mediated polymorphic transformation (SMPT) of the α-form into the β-form of taltirelin (TTL) in seeded crystallization was investigated. The kinetics of polymorph transformation of the TTL was found to be a three-dimensional growth of nuclei mechanism by the Avrami-Erofeev equation. The transformation from the α-form into the β-form was also studied by crystallization adding α-form seeds in solution. The effects of seed loading amount, temperature, supersaturation, and transformation time on polymorph transformation were evaluated. Seeded crystallization using α-form crystals as a seed nucleated the α-form TTL and then transformed the α-form into the β-form. The transformation rate was controlled by adjusting supersaturation.