Tau imaging with [up>18up>F]THK-5351 in progressive supranuclear palsy

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• 作者：A. Ishiki ; R. Harada ; N. Okamura ; N. Tomita ; C. C. Rowe ; V. L. Villemagne ; K. Yanai ; Y. Kudo ; H. Arai ; S. Furumoto ; M. Tashiro and K. Furukawa
• 刊名：European Journal of Neurology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：24
• 期：1
• 页码：130-136
• 全文大小：570K
• ISSN：1468-1331

文摘

Visualization of pathogenic protein aggregates is crucial to elucidate pathomechanisms and to make an accurate diagnosis in many neurodegenerative conditions. Aggregates of the microtubule-binding protein, tau, are one of the most important pathogenic molecules in neurodegenerative disorders. Progressive supranuclear palsy (PSP) is characterized by the deposition of tau proteins in some specific area such as the basal ganglia and brainstem. We tried to detect tau lesions in the brains of living patients with PSP with a novel positron emission tomography (PET) tracer, [up>18up>F]THK-5351, which we have recently developed.