Differential modulation of Helicobacter pylori lipopolysaccharide-mediated TLR2 signaling by individual Pellino proteins

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• 作者：Sin&eacute ; ad M. Smith ; Michael Freeley ; Paul N. Moynagh and Dermot P. Kelleher
• 刊名：Helicobacter
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：22
• 期：1
• 全文大小：844K
• ISSN：1523-5378

文摘

Eradication rates for current H. pylori therapies have fallen in recent years, in line with the emergence of antibiotic resistant infections. The development of therapeutic alternatives to antibiotics, such as immunomodulatory therapy and vaccines, requires a more lucid understanding of host–pathogen interactions, including the relationships between the organism and the innate immune response. Pellino proteins are emerging as key regulators of immune signaling, including the Toll-like receptor pathways known to be regulated by H. pylori. The aim of this study was to characterize the role of Pellino proteins in the innate immune response to H. pylori lipopolysaccharide.