Failure of primary atovaquone prophylaxis for prevention of toxoplasmosis in hematopoietic cell transplant recipients

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• 作者：K. Gajurel ; C.A. Gomez ; R. Dhakal ; H. Vogel and J.G. Montoya
• 刊名：Transplant Infectious Disease
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：18
• 期：3
• 页码：446-452
• 全文大小：376K
• ISSN：1399-3062

文摘

The efficacy of primary prophylaxis with atovaquone in preventing Toxoplasma reactivation and disease in hematopoietic cell transplant (HCT) recipients is unknown. We describe 2 cases of atovaquone prophylaxis failure in pre-HCT Toxoplasma-seropositive (pre-HCTSP) recipients who underwent allogeneic HCT (allo-HCT) and review the literature on atovaquone prophylaxis in HCT recipients.