Lactamization of sp2 C−H Bonds with CO2: Transition-Metal-Free and Redox-Neutral
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- 作者：Zhen Zhang ; Li-Li Liao ; Si-Shun Yan ; Lei Wang ; Yun-Qi He ; Jian-Heng Ye ; Dr. Jing Li ; Prof. Dr. Yong-Gang Zhi and Prof. Dr. Da-Gang Yu
- 刊名：Angewandte Chemie
- 出版年：2016
- 出版时间：June 13, 2016
- 年：2016
- 卷：128
- 期：25
- 页码：7184-7188
- 全文大小：2814K
- ISSN：1521-3757
文摘
The first direct use of carbon dioxide in the lactamization of alkenyl and heteroaryl C−H bonds to synthesize important 2-quinolinones and polyheterocycles in moderate to excellent yields is reported. Carbon dioxide, a nontoxic, inexpensive, and readily available greenhouse gas, acts as an ideal carbonyl source. Importantly, this transition-metal-free and redox-neutral process is eco-friendly and desirable for the pharmaceutical industry. Moreover, these reactions feature a broad substrate scope, good functional group tolerance, facile scalability, and easy product derivatization.