Frontispiece: Intramolecular Parallel [4+3] Cycloadditions of Cyclopropane 1,1-Diesters with [3]Dendralenes: Efficient Construction of [5.3.0]Decane and Corresponding Polycyclic Skeletons

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• 作者：Chi Zhang ; Jun Tian ; Jun Ren and Prof. Dr. Zhongwen Wang
• 刊名：Chemistry - A European Journal
• 出版年：2017
• 出版时间：January 26, 2017
• 年：2017
• 卷：23
• 期：6
• 全文大小：3338K
• ISSN：1521-3765

文摘

Cycloadditions Developing efficient and general strategies for construction of skeletally complex and diverse polycyclic skeletons in natural products is important and challenging in organic synthesis. In their Communication on page 1231 ff., Z. Wang and co-workers demonstrate a [4+3]IMPC (intramolecular parallel cycloaddition) of cyclopropane 1,1-diesters with [3]dendralenes. With a combination of the [4+3]IMPC and subsequent [4+n] cycloadditions, bridged trans-[5.3.0]decane skeleton and its corresponding structurally complex and diverse polycyclic ones are constructed efficiently. This strategy is believed to be of potential importance to natural product synthesis and drug discovery.