Increased thalamic centrality and putamen-thalamic connectivity in patients with parkinsonian resting tremor

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• 作者：Quanquan Gu ; Hengyi Cao ; Min Xuan ; Wei Luo ; Xiaojun Guan ; Jingjing Xu ; Peiyu Huang ; Minming Zhang and Xiaojun Xu
• 刊名：Brain and Behavior
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：7
• 期：1
• 全文大小：1039K
• ISSN：2157-9032

文摘

Evidence has indicated a strong association between hyperactivity in the cerebello-thalamo-motor cortical loop and resting tremor in Parkinson's disease (PD). Within this loop, the thalamus serves as a central hub based on its structural centrality in the generation of resting tremor. To study whether this thalamic abnormality leads to an alteration at the whole-brain level, our study investigated the role of the thalamus in patients with parkinsonian resting tremor in a large-scale brain network context.