Synthesis of Organofluoro Compounds Using Methyl Perfluoroalk-2-ynoates as Building Blocks

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• 作者：Xuechun Sun ; Jing Han ; Jie Chen ; Hui Zhang and Weiguo Cao
• 关键词：drug design ; fluorine ; Michael addition ; perfluoroalkyl groups ; synthetic methods
• 刊名：The Chemical Record
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：16
• 期：2
• 页码：907-923
• 全文大小：1211K
• ISSN：1528-0691

文摘

This review provides an overview of several synthetic applications of methyl perfluoroalk-2-ynoates, leading to convenient preparation of many perfluoroalkylated compounds. The use of these important substrates in the synthesis of various five-, six-, and seven-membered heterocycles, cyclopentadienes, and biphenyls is described, alongside a discussion of the mechanistic aspects of these reactions.