Smad anchor for receptor activation contributes to seizures in temporal lobe epilepsy

详细信息    查看全文

• 作者：Weihua Yu ; Yingshi Du ; Yan Zou ; Xuefeng Wang ; Ulrich Stephani and Yang Lü
• 刊名：Synapse
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：71
• 期：3
• 全文大小：644K
• ISSN：1098-2396

文摘

Smad anchor for receptor activation (SARA) is an important regulator of transforming growth factor β (TGF-β) signaling by recruiting Smad2/3 to TGF-β receptors. Although TGF-β signaling is critically involved in epileptogenesis, whether SARA activation is sufficient to facilitate TGF-β pathway to regulate epilepsy remains unknown.