D-Peptides as Recognition Molecules and Therapeutic Agents

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• 作者：Min Liu ; Xue Li ; Zuoxu Xie ; Cao Xie ; Changyou Zhan ; Xuefeng Hu ; Qing Shen ; Xiaoli Wei ; Bingxia Su ; Jing Wang and Weiyue Lu
• 刊名：The Chemical Record
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：16
• 期：4
• 页码：1772-1786
• 全文大小：454K
• ISSN：1528-0691

文摘

Over recent years, D-peptides have attracted increasing attention. D-peptides increase enzymatic stability, prolong the plasma half-life, improve oral bioavailability, and enhance binding activity and specificity with receptor or target proteins, in comparison with the corresponding L-peptide. Therefore, D-peptides are considered to have potential as recognition molecules and therapeutic agents. This review focuses on the design and application of D-peptides with biological activity.