Incorporating dixon multi-echo fat water separation for novel quantitative magnetization transfer of the human optic nerve in vivo

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• 作者：Alex K. Smith ; Richard D. Dortch ; Lindsey M. Dethrage ; Bailey D. Lyttle ; Hakmook Kang ; E. Brian Welch and Seth A. Smith
• 刊名：Magnetic Resonance in Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：77
• 期：2
• 页码：707-716
• 全文大小：3029K
• ISSN：1522-2594

文摘

The optic nerve (ON) represents the sole pathway between the eyes and brain; consequently, diseases of the ON can have dramatic effects on vision. However, quantitative magnetization transfer (qMT) applications in the ON have been limited to ex vivo studies, in part because of the fatty connective tissue that surrounds the ON, confounding the magnetization transfer (MT) experiment. Therefore, the aim of this study was to implement a multi-echo Dixon fat-water separation approach to remove the fat component from MT images.