Fibrinolytic Evaluation of Compounds Isolated from a Marine Fungus Stachybotrys longispora FG216

详细信息    查看全文

• 作者：Ruihua Guo ; Yiting Zhang ; Dong Duan ; Qiang Fu ; Xiangyu Zhang ; Xiaowei Yu ; Shujun Wang ; Bin Bao and Wenhui Wu
• 刊名：Chinese Journal of Chemistry
• 出版年：2016
• 出版时间：November, 2016
• 年：2016
• 卷：34
• 期：11
• 页码：1194-1198
• 全文大小：403K
• ISSN：1614-7065

文摘

As a part of our continuing work to discover bioactive leading molecules from marine microorganism, ethyl acetate fraction of organic extract of the train Stachybotrys longispora FG216 showed fibrinolytic activity in our primary screen. The bioassay-guided purification of the active fractions resulted in isolation of a new isoindolone, FGFC2 (1) (FGFC2, Fungi fibrinolytic compound 2), together with two known compounds, LL-Z1272β (2) and ergosterol (3). The structure of compound 1 was elucidated by the spectral analysis of 1D (¹H, ¹³C) NMR, 2D (COSY, HSQC, and HMBC) and ESI-MS. Three compounds were evaluated for fibrinolytic activities in vitro. Compared to FGFC1 (EC₅₀47 µmol/L) as a reference drug, compound 1 and ergosterol (3) showed moderate fibrinolytic activities in vitro with EC₅₀ values of 108.16 and 156.30 µmol/L, respectively. LL-Z1272β (2) had no fibrinolytic activity.