Frontispiece: Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light
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- 作者：Luke K. McKenzie ; Dr. Igor V. Sazanovich ; Dr. Elizabeth Baggaley ; Dr. Mickaë ; le Bonneau ; Dr. Vé ; ronique Guerchais ; Prof. J. A. Gareth Williams ; Prof. Julia A. Weinstein and Dr. Helen E. Bryant
- 刊名：Chemistry - A European Journal
- 出版年：2017
- 出版时间：January 5, 2017
- 年：2017
- 卷：23
- 期：2
- 全文大小：2767K
- ISSN：1521-3765
文摘
Complexes for Photodynamic Therapy In their Communication on ef="https://doi.org/10.1002/chem.201604792" rel="references:https://doi.org/10.1002/chem.201604792">page 234 ff., J. A. Weinstein, H. E. Bryant et al. present two low-molecular-weight, long-lived and photo-stable iridium complexes of the [Ir(N C)2(N N)]+ family which have high two-photon absorption and localise to mitochondria and lysosomal structures. Both are efficient photosensitizers (PS) under 1-photon irradiation resulting in apoptotic death in cancer cell lines at low light doses, low concentrations, and high photo-indices. Complex 1 also displays high PS activity under NIR two-photon excitation, which along with its photo-stability indicates potential future clinical application.