Involvement of the Hippocampus in Binge Ethanol-Induced Spleen Atrophy in Adolescent Rats

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• 作者：Xiangqian Liu ; Kaitlyn P. Connaghan ; Yufeng Wei ; Zhongli Yang ; Ming D. Li and Sulie L. Chang
• 刊名：Alcoholism: Clinical and Experimental Research
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：40
• 期：7
• 页码：1489-1500
• 全文大小：876K
• ISSN：1530-0277

文摘

Ethanol (EtOH) affects the immune system. Binge drinking of hard liquor initiates a stress response. This form of drinking is popular during adolescence, which involves maturation of the immune system. The spleen is a key immune organ, and spleen atrophy is associated with immunosuppression. While the hypothalamic–pituitary–adrenal (HPA) axis plays a key role in the initial stress response, the hippocampus may be involved in stress beyond the HPA axis.