Adjuvant Treatment with Yupingfeng Formula for Recurrent Respiratory Tract Infections in Children: A Meta-analysis of Randomized Controlled Trials

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• 作者：Tao Song ; Xiaoli Hou ; Xiaohui Yu ; Zhen Wang ; Ruiren Wang ; Yanling Li ; Dan Hu ; Xiaohong Wang ; Zhengzheng Xiao ; Yong Sui ; Chunhong Zhu and Jing Wang
• 刊名：Phytotherapy Research
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：30
• 期：7
• 页码：1095-1103
• 全文大小：346K
• ISSN：1099-1573

文摘

This meta-analysis aimed to evaluate the immunomodulating function of Yupingfeng Formula (YPFF) in children with recurrent respiratory tract infections (RRTIs). The PubMed, EMBASE, Cochrane Library, CNKI and WanFang databases were searched for randomized controlled trials comparing with and without YPFF for RRTIs in children. Twelve trials with 1236 patients were identified. Adjuvant treatment with YPFF significantly increased serum levels of IgA (weighted mean difference [WMD] 0.33 mg/mL; 95% confidence interval [CI] 0.20 to 0.45), IgG (WMD 1.36 mg/mL; 95% CI 1.06 to 1.65), IgM (WMD 0.16 mg/mL; 95% CI 0.02 to 0.31), and CD3⁺ T-lymphocytes (WMD 10.16%; 95% CI 4.62 to 15.69) but not CD4⁺ T-lymphocytes (WMD 3.16%; 95% CI −0.27 to 6.59) and CD8⁺ T-lymphocytes (WMD −0.84%; 95% CI −2.50 to 0.81). YPFF also reduced the frequency of RRTIs (WMD −3.80 times; 95% CI −4.86 to −2.74) and increased total effective rates of symptom improvement (risk ratio: 1.44; 95% CI 1.19 to 1.75). Adjuvant treatment with YPFF could improve total clinical effective rate and decrease the frequency of respiratory tract infections in children with RRTIs. The beneficial effects of YPFF may be correlated to its immunomodulating action. More well-designed trials with larger sample sizes are needed to evaluate its efficacy and safety. Copyright