Facile Synthesis of 3-Halobenzo-heterocyclic-2-carbonyl Compounds via in situ Halogenation-Oxidation

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• 作者：Xiaojian Jiang ; Junjie Yang ; Feng Zhang ; Pei Yu ; Peng Yi ; Yewei Sun and Yuqiang Wang
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2016
• 出版时间：August 18, 2016
• 年：2016
• 卷：358
• 期：16
• 页码：2678-2683
• 全文大小：754K
• ISSN：1615-4169

文摘

A facile method to synthesize 3-halobenzo-heterocyclic-2-carbonyl compounds is described. Mechanistic studies suggested that a halo-cyclization process, which generated the unstable spiro-acetal transition state and readily convertible to the corresponding carbonyl compound might be involved. Diverse 3-halobenzo-heterocyclic-2-carbonyl compounds could be synthesized with up to 95 % yield in mild conditions with inexpensive starting materials.