Tetrahydrobiopterin contributes to the proliferation of mesangial cells and accumulation of extracellular matrix in early-stage diabetic nephropathy

详细信息    查看全文

• 作者：Jianyun Wang ; Qianqian Yang ; Yaxing Nie ; Hao Guo ; Fan Zhang ; Xueyan Zhou and Xiaoxing Yin
• 刊名：Journal of Pharmacy and Pharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：69
• 期：2
• 页码：182-190
• 全文大小：705K
• ISSN：2042-7158

文摘

Nitric oxide (NO) plays an important role in the progression of early-stage diabetic nephropathy (DN), which is found to contribute to extracellular matrix (ECM) accumulation in mesangial cells (MCs). As a cofactor for NO production, tetrahydrobiopterin (BH₄), a folacin analogue, may be responsible for the ECM accumulation and proliferation of MCs. This study was to investigate the effects of BH₄ on glomerulosclerosis in early-stage DN.