Neuroprotective Effects of rhGLP-1 in Diabetic Rats with Cerebral Ischemia/Reperfusion Injury
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- 作者：Daoli Jiang ; Yitong Wang ; Yannan Zang ; Xiaofang Liu ; Libo Zhao ; Qian Wang ; Chang Liu ; Wanyu Feng ; Xiaoxing Yin and Yi Fang
- 关键词：rhGLP-1 ; cerebral ischemia/reperfusion injury ; diabetes
- 刊名：Drug Development Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：77
- 期：3
- 页码：124-133
- 全文大小：307K
- ISSN：1098-2299
文摘
The aim of the present study was to evaluate the neuroprotective benefits of rhGLP-1 in diabetic rats subjected to acute cerebral ischemia/reperfusion injury induced by middle cerebral artery occlusion/reperfusion (MCAO/R). Streptozotocin (STZ)-induced diabetic rats were pretreated with rhGLP-1 (10, 20, or 40 μg/kg ip, tid) for 14 days. During this time, body weight and fasting blood glucose levels were assessed. Rats were then subjected to MCAO 90 min/R 24 h. At 2 and 24 h of reperfusion, rats were evaluated for neurological deficits and blood samples were collected to analyze markers of brain injury. Rats were then sacrificed to assess the infarction volume. rhGLP-1 pretreatment lowered blood glucose levels, improved neurological scores, attenuated infarct volumes, and reduced the blood levels of S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), and myelin basic protein (MBP). rhGLP-1 has neuroprotective benefits in diabetic rats with cerebral ischemia/reperfusion injury and could potentially be used as a prophylatic neuroprotectant in diabetic patients at high risk of ischemic stroke. Drug Dev Res 77 : 124–133, 2016.