Bone substitute of poly(amino acid)/β-Ca2SiO4 biocomposite: Degradability and bioactivity

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• 作者：Jie Wang ; Hong Li ; Xiaoxia Fan ; Tianwei Li ; Guoyu Lv and Yonggang Yan
• 刊名：Polymer Composites
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：37
• 期：5
• 页码：1335-1341
• 全文大小：674K
• ISSN：1548-0569

文摘

A poly(amino acid)/β-Ca₂SiO₄(PAA/β-Ca₂SiO₄) bioactive composite was prepared by in situ melting polymerization. The composition, structure, and morphology were characterized by infrared spectrometry, X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, and differential scanning calorimeter. The results indicated that the β-Ca₂SiO₄ particles were uniformly distributed in the PAA matrix and some interaction was found at the interface between PAA and β-Ca₂SiO₄. The crystallinity of PAA in the composite was found decreasing with the increase of β-Ca₂SiO₄ content. The bioactivity of the composite was evaluated by soaking the composite in simulated body fluid (SBF) and results showed that the PAA/β-Ca₂SiO₄ composite (PSC) could induce a dense and continuous layer of apatite after soaking for 1 week. In addition, the PSC was soaked SBF for 2 months, and the weight loss reached 8.77%, showing the composite could be degradable. Collectively, these results suggested that the incorporation of β-Ca₂SiO₄ produced a biocomposite with enhanced bioactivity and might have potential applications as a bone tissue substitute. POLYM. COMPOS., 37:1335–1341, 2016.