Development of Axially Chiral Cyclo-Biaryldiol Ligands with Adjustable Dihedral Angles
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- 作者：Pengxiang Zhang ; Dr. Jipan Yu ; Fei Peng ; Xudong Wu ; Jiyang Jie ; Can Liu ; Hua Tian ; Dr. Haijun Yang and Prof. Dr. Hua Fu
- 刊名：Chemistry - A European Journal
- 出版年：2016
- 出版时间：November 21, 2016
- 年：2016
- 卷：22
- 期：48
- 页码：17477-17484
- 全文大小：869K
- ISSN：1521-3765
文摘
A new type of axially chiral cyclo-[1,1′-biphenyl]-2,2′-diol (CYCNOL) ligands with adjustable dihedral angles have been developed by varying the bridge chain length. Eight-, nine- and ten-membered cyclo-ligands were prepared and evaluated by using two representative examples: enantioselective additions of diethylzinc to aldehydes and organometallic reagents to enones. The results revealed that the fine regulation of dihedral angles through variation of the bridge chain length was effective in the asymmetric synthesis.