Proton spectroscopy study of the dorsolateral prefrontal cortex in youth with familial depression

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• 作者：Xiao-Ru Yang ; Lisa Marie Langevin ; Natalia Jaworska ; Adam Kirton ; R. Marc Lebel ; Ashley D. Harris ; Yamile Jasaui ; T. Christopher Wilkes ; Mariko Sembo ; Rose Swansburg and Frank P. MacMaster
• 刊名：Psychiatry and Clinical Neurosciences
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：70
• 期：7
• 页码：269-277
• 全文大小：461K
• ISSN：1440-1819

文摘

Structural, functional, and metabolic changes in the dorsolateral prefrontal cortex (DLPFC) are implicated in the pathogenesis of major depressive disorder (MDD). We used proton magnetic resonance spectroscopy (¹ H-MRS) to examine the metabolite choline (glycerophosphocholine plus phosphocholine), which is used as an index of membrane integrity in the left DLPFC, in adolescents and young adults with MDD who were treatment-resistant and had a positive family history compared to healthy controls. Differences in the choline resonance indicate an imbalance between synthesis and degradation activity of neuronal and glia membrane phospholipids.