Cobalt-Catalyzed Enantio- and Diastereoselective Intramolecular Hydroacylation of Trisubstituted Alkenes

详细信息    查看全文

• 作者：Dr. Junfeng Yang ; Dr. Alice Ré ; rat ; Yang Jie Lim ; Dr. Corinne Gosmini and Prof. Naohiko Yoshikai
• 刊名：Angewandte Chemie
• 出版年：2017
• 出版时间：February 20, 2017
• 年：2017
• 卷：129
• 期：9
• 页码：2489-2493
• 全文大小：773K
• ISSN：1521-3757

文摘

Enantio- and diastereoselective synthesis of trans-2,3-disubstituted indanones is achieved by intramolecular hydroacylation of 2-alkenylbenzaldehydes bearing trisubstituted alkenyl groups under cobalt-chiral diphosphine catalysis. Notably, a high level of enantioselectivity is induced regardless of the stereochemistry (E/Z ratio) of the alkenyl group of the starting material. Deuterium-labeling experiments shed light on the productive reaction pathways of the E- and Z-isomers.