Switchable catalysts in flexible MOFs are possible through the inherent cavities and dynamic behaviors of flexible metal–organic frameworks (MOFs), namely the PCN-700 series, properties that bear a close resemblance to those of regulatory enzymes. In their Communication on
page 10776 ff., W. Lu, M. B. Hall, H.-C. Zhou, and co-workers show that manual control of the catalytic properties of these MOFs is possible through reversible pore opening and closing.